Zanidatamab-hrli Injection

WHY is this medicine prescribed?

Zanidatamab-hrli injection is used to treat certain type of biliary tract cancer that cannot be operated on, have failed to respond to other treatments or that has spread. Zanidatamab-hrli injection is in a class of medications called monoclonal antibodies. It works by stopping the growth of the tumor.

HOW should this medicine be used?

Zanitamab-hrli injection comes as a powder to be mixed with a liquid and to be given as an intravenous infusion (infusion into the vein) by a doctor or a nurse at a healthcare facility. It is usually given every 2 weeks. Your doctor will decide how long you should receive zanitamab-hrli injection. Your dose may need to be changed, delayed or held based on how you are tolerating the medicine.

Zanitamab-hrli injection can cause reactions during the infusion. Let your doctor know if you experience any of the following during your zanitamab-hrli infusion: itching, flushing, rash, fever, chills, muscle or joint pain, fast heartbeat, shortness of breath, cough, chest discomfort, dizziness or lightheadedness, or sudden anxiety. Your doctor will give you additional medicines before each dose of zanitamab-hrli to help prevent any reactions while receiving zanitamab-hrli.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before receiving zanitamab-hrli,

• tell your doctor and pharmacist if you are allergic to zanitamab-hrli, any other medications, or any of the ingredients in zanitamab-hrli injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have or have ever had any heart problems.
• talk to your doctor about risks and benefits of breastfeeding while receiving zanitamab-hrli.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

If you miss a scheduled infusion of zanitamab-hrli, call your doctor to set up an appointment to receive it right away. Then restart the infusion schedule so that zanitiamab=hrli is given every 2 weeks.

What SIDE EFFECTS can this medicine cause?

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• diarrhea
• new or worsening shortness of breath, feeling more tired than usual, swelling of your ankles or feet, loss of consciousness, irregular heartbeat, sudden weight gain, dizziness or lightheadedness

Zanitiamab-hrli injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to zanitamab-hrli injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: December 15, 2024.